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Iodine Research

Resource Network of The Iodine Movement

                             Iodine and the Body


Radioiodine uptake in inactive pulmonary tuberculosis.
Bakheet SM, Hammami MM, Powe J, Bazarbashi M, Al Suhaibani H.
Eur J Nucl Med. 1999 Jun;26(6):659-62.
[abstract only]

Radioiodine may accumulate at sites of inflammation or infection. We have seen such accumulation
in six thyroid cancer patients with a history of previously treated pulmonary tuberculosis. We also
review the causes of false-positive radioiodine uptake in lung infection/inflammation. Eight foci of
radioiodine uptake were seen on six iodine-123 diagnostic scans. In three foci, the uptake was focal
and indistinguishable from thyroid cancer pulmonary metastases from thyroid cancer. In the
remaining foci, the uptake appeared nonsegmental, linear or lobar, suggesting a false-positive
finding. The uptake was unchanged, variable in appearance or non-persistent on follow-up scans
and less extensive than the fibrocystic changes seen on chest radiographs. In the two patients
studied, thyroid hormone level did not affect the radioiodine lung uptake and there was congruent
gallium-67 uptake. None of the patients had any evidence of thyroid cancer recurrence or of
reactivation of tuberculosis and only two patients had chronic intermittent chest symptoms. Severe
bronchiectasis, active tuberculosis, acute bronchitis, respiratory bronchiolitis, rheumatoid
arthritis-associated lung disease and fungal infection such as Allescheria boydii and aspergillosis
can lead to different patterns of radioiodine chest uptake mimicking pulmonary metastases.
Pulmonary scarring secondary to tuberculosis may predispose to localized radioiodine accumulation
even in the absence of clinically evident active infection. False-positive radioiodine uptake due to
pulmonary infection/inflammation should be considered in thyroid cancer patients prior to the
diagnosis of pulmonary metastases.

Intermittent therapy with potassium iodide in chronic obstructive disease of the airways. A review of
10 years' experience.
Bernecker C.
Acta Allergol. 1969 Sep;24(3):216-25.
[citation only]

Iodine-131 uptake in inflammatory lung disease: a potential pitfall in treatment of thyroid carcinoma.
Hoschl R, Choy DH, Gandevia B.
J Nucl Med. 1988 May;29(5):701-6.

A mixed differentiated thyroid carcinoma was found in a small asymptomatic nodule in a 44-yr-old
woman with recurrent chest infections and bronchiectasis. After total thyroidectomy and 162 mCi (6
GBq) radioiodine ablation there was uptake in the thyroid remnant and in both lungs, interpreted as
lung metastases. In 2 years she received further three 162 mCi (6 GBq) doses of 131I, as scans
showed very similar lung activity. Another scan, during thyroxin suppression, showed again activity
in the lungs. A 47-yr-old male patient with similar respiratory disease and no history of thyroid
disorder volunteered to undergo radioiodine scan while on triiodothyronine suppression. His scan,
too, showed concentration in the lungs. The female patient died 7 years after the diagnosis of lung
thyroid metastases was made. No metastasis was found at autopsy. Radioiodine lung uptake may
occur in patients with chronic inflammatory lung disease, presenting a potential diagnostic pitfall in
patients with differentiated thyroid carcinoma.

Inflammatory diseases of the lung causing false-positive 131iodine whole body scans in the
evaluation of papillary thyroid carcinoma. Two case reports.
Pina JS, Meyer CA, Billingsley JL, Matlock JP, Horan MP, Knodel DH.
Chest. 1996 Aug;110(2):565-7.

"The 131I whole body scan is commonly used to establish the presence of metastatic disease in
papillary thyroid carcinoma. False-positive scans are rare, but have been reported. We present two
cases of aberrant uptake of radioiodine after thyroidectomy and 131I ablation due to inflammatory
conditions of the lung, aspergilloma, and respiratory bronchiolitis."

One Mineral Can Help a Myriad of Conditions from Atherosclerosis to "COPD" to Zits
Wright J

If you have chronic bronchitis and or emphysema ("COPD", "COLD") SSKI is an invaluable tool. SSKI
"gets into" all body secretions, including often thick and hard to cough up bronchial secretions,
which get infected very easily. SSKI takes care of both of these problems. It "loosens" secretions
remarkably, making them much easier to "clear", and it prevents micro-organisms from growing
easily. With regular SSKI use, bronchial infection is a much less frequent happening. Depending on
the severity of COPD, I recommend 3 to 6 drops of SSKI taken in water once daily. As COPD is
usually a chronic condition, SSKI use will usually be indefinite, so make sure to monitor your thyroid


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